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Advanced Search Results For "WESTERN immunoblotting"

1 - 10 of 56,656 results for
 "WESTERN immunoblotting"
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MiR-29b-3p Inhibits the Inflammation Injury in Human Umbilical Vein Endothelial Cells by Regulating SEC23A.

Publication Type: Academic Journal

Source(s): Biochemical Genetics. Dec2022, Vol. 60 Issue 6, p2000-2014. 15p.

Abstract: This study aims to investigate the effects of miR-29b-3p on the inflammation injury of human umbilical vein endothelial cells (HUVECs) induced by lipopolysaccharide (LPS) and explore the underlying mechanisms. The effects of different concentrations of...

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New pyrazolone derivatives, synthesis, characterization, and neuroprotective effect against PTZ-induced neuroinflammation in mice.

Publication Type: Academic Journal

Source(s): Iranian Journal of Basic Medical Sciences. Dec2022, Vol. 25 Issue 12, p1424-1432. 9p.

Abstract: Objective(s): The study was aimed at synthesis of the new derivatives of the pyrazolone nucleus, and their spectroscopic and pharmacological analysis and evaluation. Materials and Methods: Three series of compounds, with 2-picolinic acid (I a-d), 3-pic...

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A mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells.

Publication Type: Academic Journal

Source(s): Scientific Reports. 11/23/2022, Vol. 12 Issue 1, p1-14. 14p.

Abstract: Karyopherin beta 1 (Kpnβ1) is the principal nuclear importer of cargo proteins and plays a role in many cellular processes. Its expression is upregulated in cancer and essential for cancer cell viability, thus the identification of its binding partners...

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GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice.

Publication Type: Academic Journal

Source(s): International Journal of Molecular Sciences. Nov2022, Vol. 23 Issue 22, p13748. 13p.

Abstract: The UPR is sustainably activated in degenerating retinas, leading to translational inhibition via p-eIF2α. Recent findings have demonstrated that ablation of growth arrest and DNA damage-inducible protein 34 (GADD34), a protein phosphatase 1 regulatory...

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Identification of Dihydrolipoamide Dehydrogenase as Potential Target of Vemurafenib-Resistant Melanoma Cells.

Publication Type: Academic Journal

Source(s): Molecules. Nov2022, Vol. 27 Issue 22, p7800. 21p.

Abstract: Background: Despite recent improvements in therapy, the five-year survival rate for patients with advanced melanoma is poor, mainly due to the development of drug resistance. The aim of the present study was to investigate the mechanisms underlying thi...

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Metformin Suppresses Hepatocellular Carcinoma through Regulating Alternative Splicing of LGR4.

Publication Type: Academic Journal

Source(s): Journal of Oncology. 11/4/2022, Vol. 2022, p1-9. 9p.

Abstract: Background and aims. Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide. The role of leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) in HCC remains unclear. Metformin can prevent and c...

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Cholinergic signaling impairs cardiomyocyte cohesion.

Publication Type: Academic Journal

Source(s): Acta Physiologica. Nov2022, Vol. 236 Issue 3, p1-16. 16p. 1 Chart, 8 Graphs.

Abstract: Aim: Cardiac autonomic nervous system (ANS) dysregulation is a hallmark of several cardiovascular diseases. Adrenergic signaling enhanced cardiomyocyte cohesion via PKA‐mediated plakoglobin phosphorylation at serine 665, referred to as positive adhesio...

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MicroRNA‐582‐5p targeting Creb1 modulates apoptosis in cardiomyocytes hypoxia/reperfusion‐induced injury.

Publication Type: Academic Journal

Source(s): Immunity, Inflammation & Disease. Nov2022, Vol. 10 Issue 11, p1-13. 13p.

Abstract: Background: Myocardial ischemia–reperfusion injury (MIRI) caused by the reperfusion therapy of myocardial ischemic diseases is a kind of major disease that threatens human health and lives severely. There are lacking of effective therapeutic measures f...

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Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration-Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress.

Publication Type: Academic Journal

Source(s): Cancers. Nov2022, Vol. 14 Issue 21, p5260. 26p.

Abstract: Simple Summary: Prostate cancer (PCa) is the second leading cause of cancer death in men in the United States. The emergence of resistance to androgen deprivation therapy results in castration-resistant prostate cancer (CRPC) development. Taxanes are d...

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Production of a monoclonal antibody specific to sablefish (Anoplopoma fimbria) IgM and its application in ELISA, western blotting, and immunofluorescent staining.

Publication Type: Academic Journal

Source(s): Fish & Shellfish Immunology. Nov2022, Vol. 130, p479-489. 11p.

Abstract: Sablefish (Anoplopoma fimbria) are an emerging aquaculture species native to the continental shelf of the northern Pacific Ocean. There is limited information on both innate and adaptive immunity for this species and new tools are needed to determine a...

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