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Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial.
Publication Type: Academic Journal
Source(s): JAMA [JAMA] 2023 Apr 04; Vol. 329 (13), pp. 1078-1087.
Abstract: Importance: In patients with coronary artery disease, some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is to begin...
High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database.
Publication Type: Academic Journal
Source(s): Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2023 Apr; Vol. 49, pp. 100486. Date of Electronic Publication: 2022 Dec 07.
Abstract: Drug interactions between atorvastatin and cytochrome P450 (P450) 3A substrates/inhibitors lead to an increased incidence of skeletal muscle or hepatic toxicity. However, in this survey, among 483 Japanese subjects administered atorvastatin alone, more...
[Influence of Loading Dose Of Atorvastatin on the Risk of Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction].
Publication Type: Academic Journal
Source(s): Kardiologiia [Kardiologiia] 2023 Feb 28; Vol. 63 (2), pp. 34-39. Date of Electronic Publication: 2023 Feb 28.
Abstract: Aim This retrospective cohort study focused on evaluating the incidence of contrast-induced nephropathy (CIN) associated with administration of an atorvastatin loading dose (80 mg) prior to invasive coronary angiography (CAG) in patients with ST-s...
Drug Eruption From Atorvastatin: With Initial Misdiagnosis of Tinea Cruris .
Publication Type: Academic Journal
Source(s): The Senior care pharmacist [Sr Care Pharm] 2023 Feb 01; Vol. 38 (2), pp. 63-69.
Abstract: Objective To present the case of a Latin man 68 years of age who presented to the emergency department with a rash to the right side of his groin 10 weeks after switching from simvastatin 40 mg daily to atorvastatin 40 mg daily. Background Prior to swi...
Atorvastatin induces downregulation of matrix metalloproteinase-2/9 in MDA-MB-231 triple negative breast cancer cells.
Publication Type: Academic Journal
Source(s): Medical oncology (Northwood, London, England) [Med Oncol] 2022 Nov 29; Vol. 40 (1), pp. 22. Date of Electronic Publication: 2022 Nov 29.
Abstract: Matrix metalloproteinases (MMPs) are a family of endopeptidases, mainly responsible of extracellular tissue remodeling. Abundant expression of MMPs leads to a number of tumorigenic processes including proliferation, angiogenesis, metastasis and invasio...
Hot-Melt Extrusion-Based Fused Deposition Modeling 3D Printing of Atorvastatin Calcium Tablets: Impact of Shape and Infill Density on Printability and Performance.
Publication Type: Academic Journal
Source(s): AAPS PharmSciTech [AAPS PharmSciTech] 2022 Dec 07; Vol. 24 (1), pp. 13. Date of Electronic Publication: 2022 Dec 07.
Abstract: The main objective of the current research was to investigate the effect of tablet shapes (heart-shaped and round tablets) and infill densities (50% and 100%) on the drug release profiles of 3D printed tablets prepared by hot-melt extrusion paired with...
SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients.
Publication Type: Academic Journal
Source(s): Pharmacogenomics [Pharmacogenomics] 2022 Aug; Vol. 23 (12), pp. 683-694. Date of Electronic Publication: 2022 Aug 15.
Abstract: Introduction: Atorvastatin exhibits wide interindividual variability in treatment response, limiting the drug efficacy in coronary artery disease patients. Aim: To study the effect of genetic variants involved in atorvastatin transport/metabolism and c...
The preventive effects of different doses of atorvastatin on contrast-induced acute kidney injury after CT perfusion.
Publication Type: Academic Journal
Source(s): Journal of clinical laboratory analysis [J Clin Lab Anal] 2022 Jul; Vol. 36 (7), pp. e24386. Date of Electronic Publication: 2022 May 17.
Abstract: Background: Contrast-induced acute kidney injury (CI-AKI) is a severe complication among patients receiving intravascular contrast media. The purpose of this study was to investigate the preventive effects of pretreatment of atorvastatin at intensive d...
Hepatotoxicity in young adult rat offspring after prenatal exposure to benzo(a)pyrene, and protective effect of atorvastatin.
Publication Type: Academic Journal
Source(s): Birth defects research [Birth Defects Res] 2022 Jul 01; Vol. 114 (11), pp. 551-558. Date of Electronic Publication: 2022 May 20.
Abstract: Objectives: Benzo[a]pyrene (BaP) is an environmental contaminant that interrupts the antioxidant defense and thus leads to oxidative stress and DNA damage in the liver. Atorvastatin (ATV) for reducing cholesterol has antioxidant and anti-apoptotic acti...
In silico and in vitro assessment of anti-Trypanosoma cruzi efficacy, genotoxicity and pharmacokinetics of pentasubstituted pyrrolic Atorvastatin-aminoquinoline hybrid compounds.
Publication Type: Academic Journal
Source(s): Acta tropica [Acta Trop] 2023 Jun; Vol. 242, pp. 106924. Date of Electronic Publication: 2023 Apr 08.
Abstract: Atorvastatin (AVA) is a third-generation statin with several pleiotropic effects, considered the last synthetic pharmaceutical blockbuster. Recently, our group described the effects of AVA on DNA damage prevention and against Trypanosoma cruzi infectio...