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Advanced Search Results For "break"

1 - 10 of 30,437 results for
 "break"
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DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development.

Publication Type:Academic Journal

Source(s):DNA repair [DNA Repair (Amst)] 2022 Oct; Vol. 118, pp. 103386. Date of Electronic Publication: 2022 Aug 04.

Abstract:Spermatogenesis is a complex developmental process. During this process, male germ cells from spermatogonia to sperm cells encounter a number of DNA damages. The most severe form of these damages is double-strand breaks (DSBs) deriving from exogenous a...

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From fluorescent foci to sequence: Illuminating DNA double strand break repair by high-throughput sequencing technologies.

Publication Type:Academic Journal

Source(s):DNA repair [DNA Repair (Amst)] 2022 Oct; Vol. 118, pp. 103388. Date of Electronic Publication: 2022 Aug 19.

Abstract:Technologies to study DNA double-strand break (DSB) repair have traditionally mostly relied on fluorescence read-outs, either by microscopy or flow cytometry. The advent of high throughput sequencing (HTS) has created fundamentally new opportunities to...

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Exploring the SSBreakome: genome-wide mapping of DNA single-strand breaks by next-generation sequencing.

Publication Type:Academic Journal

Source(s):The FEBS journal [FEBS J] 2021 Jul; Vol. 288 (13), pp. 3948-3961. Date of Electronic Publication: 2020 Oct 02.

Abstract:Mapping the genome-wide distribution of DNA lesions is key to understanding damage signalling and DNA repair in the context of genome and chromatin structure. Analytical tools based on high-throughput next-generation sequencing have revolutionized our ...

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To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining.

Publication Type:Academic Journal

Source(s):DNA repair [DNA Repair (Amst)] 2022 Oct; Vol. 118, pp. 103380. Date of Electronic Publication: 2022 Jul 30.

Abstract:Chromosomal DNA double-strand breaks (DSBs) are the effective lesion of radiotherapy and other clastogenic cancer therapeutics, and are also the initiating event of many approaches to gene editing. Ligation of the DSBs by end joining (EJ) pathways can ...

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Global chromatin mobility induced by a DSB is dictated by chromosomal conformation and defines the HR outcome.

Publication Type:Academic Journal

Source(s):ELife [Elife] 2022 Sep 20; Vol. 11. Date of Electronic Publication: 2022 Sep 20.

Abstract:Repair of DNA double-strand breaks (DSBs) is crucial for genome integrity. A conserved response to DSBs is an increase in chromatin mobility that can be local, at the site of the DSB, or global, at undamaged regions of the genome. Here, we address the ...

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Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells.

Publication Type:Academic Journal

Source(s):Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2022 Aug 22; Vol. 41 (1), pp. 256. Date of Electronic Publication: 2022 Aug 22.

Abstract:Background: Triple-negative breast cancer (TNBC) is associated with aggressiveness and a poor prognosis. Besides surgery, radiotherapy serves as the major treatment modality for TNBC. However, response to radiotherapy is limited in many patients, most ...

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The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.

Publication Type:Academic Journal

Source(s):Cells [Cells] 2022 Aug 17; Vol. 11 (16). Date of Electronic Publication: 2022 Aug 17.

Abstract:DNA double-strand breaks (DSBs) represent the molecular origin of ionizing-radiation inflicted biological effects. An increase in the ionization density causes more complex, clustered DSBs that can be processed by resection also in G1 phase, where repa...

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Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination.

Publication Type:Academic Journal

Source(s):International journal of molecular sciences [Int J Mol Sci] 2022 Aug 16; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 16.

Abstract:In the cells of higher eukaryotes, sophisticated mechanisms have evolved to repair DNA double-strand breaks (DSBs). Classical nonhomologous end joining (c-NHEJ), homologous recombination (HR), alternative end joining (alt-EJ) and single-strand annealin...

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Role of H4K16 acetylation in 53BP1 recruitment to double-strand break sites in in vitro aged cells.

Publication Type:Academic Journal

Source(s):Biogerontology [Biogerontology] 2022 Aug; Vol. 23 (4), pp. 499-514. Date of Electronic Publication: 2022 Jul 18.

Abstract:Increased frequency of DNA double strand breaks (DSBs) with aging suggests an age-associated decline in DSB repair efficiency, which is also influenced by the epigenetic landscape. H4 acetylation at lysine 16 (H4K16Ac) has been related to DSB repair si...

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Target residence of Cas9-sgRNA influences DNA double-strand break repair pathway choices in CRISPR/Cas9 genome editing.

Publication Type:Academic Journal

Source(s):Genome biology [Genome Biol] 2022 Aug 01; Vol. 23 (1), pp. 165. Date of Electronic Publication: 2022 Aug 01.

Abstract:Background: Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways. Target interaction of Cas9-sgRNA determines its target binding affinity a...

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