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Advanced Search Results For "cytokines"

1 - 10 of 357,078 results for
 "cytokines"
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Ad-hoc modifications of cyclic mimetics of SOCS1 protein: Structural and functional insights.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114781. Date of Electronic Publication: 2022 Sep 19.

Abstract: Suppressors of cytokine signaling 1 (SOCS1) protein, a negative regulator of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, possesses a small kinase inhibitory region (KIR) involved in the inhibition of JAK kina...

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IL-6/IFN-γ double knockdown CAR-T cells reduce the release of multiple cytokines from PBMCs in vitro.

Publication Type: Academic Journal

Source(s): Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2022 Dec 31; Vol. 18 (1), pp. 1-14. Date of Electronic Publication: 2022 Jan 20.

Authors:

Abstract: CD19-targeted chimeric antigen receptor T (anti-CD19 CAR-T) cells have shown good therapeutic results in the treatment of CD19 + B cell acute lymphocytic leukemia and lymphoma. However, severe side reactions and cytotoxicity are great challenges in the...

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MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma.

Publication Type: Academic Journal

Source(s): Cancer research [Cancer Res] 2022 Nov 15; Vol. 82 (22), pp. 4191-4205.

Authors:

Abstract: Tumor metastasis is one of the major causes of high mortality in patients with hepatocellular carcinoma (HCC). Sustained activation of STAT3 signaling plays a critical role in HCC metastasis. RNA binding protein (RBP)-mediated posttranscriptional regul...

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TriTECM: A tetrafunctional T-cell engaging antibody with built-in risk mitigation of cytokine release syndrome.

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Nov 10; Vol. 13, pp. 1051875. Date of Electronic Publication: 2022 Nov 10 (Print Publication: 2022).

Abstract: Harnessing the innate power of T cells for therapeutic benefit has seen many shortcomings due to cytotoxicity in the past, but still remains a very attractive mechanism of action for immune-modulating biotherapeutics. With the intent of expanding the t...

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SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2022 Nov 05; Vol. 241, pp. 114659. Date of Electronic Publication: 2022 Aug 08.

Authors:

Abstract: Cytokine storm is a key feature of sepsis and severe stage of COVID-19, and the immunosuppression after excessive immune activation is a substantial hazard to human life. Both pathogen-associated molecular patterns (PAMPs) and damage-associated molecul...

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Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response.

Publication Type: Academic Journal

Source(s): Immunology [Immunology] 2022 Oct; Vol. 167 (2), pp. 165-180. Date of Electronic Publication: 2022 Aug 10.

Abstract: Cytokine release syndromes represent a severe turn in certain disease states, which may be caused by several infections, including those with the virus SARS-CoV-2. This inefficient, even harmful, immune response has been associated with a broad release...

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Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection.

Publication Type: Academic Journal

Source(s): Viruses [Viruses] 2022 Nov 09; Vol. 14 (11). Date of Electronic Publication: 2022 Nov 09.

Abstract: CNS viral infections are one of the major causes of morbidity and mortality worldwide and a significant global public health concern. Uncontrolled inflammation and immune responses in the brain, despite their protective roles, can also be harmful. The ...

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The Cytokine Release Syndrome and/or the Proinflammatory Cytokines as Underlying Mechanisms of Downregulation of Drug Metabolism and Drug Transport: A Systematic Review of the Clinical Pharmacokinetics of Victim Drugs of this Drug-Disease Interaction Under Different Clinical Conditions.

Publication Type: Academic Journal

Source(s): Clinical pharmacokinetics [Clin Pharmacokinet] 2022 Nov; Vol. 61 (11), pp. 1519-1544. Date of Electronic Publication: 2022 Sep 05.

Authors:

Abstract: Background and Objective: An ever-growing body of evidence supports the impact of cytokine modulation on the patient's phenotypic drug response. The aim of this systematic review was to analyze the clinical studies that assessed the pharmacokinetics of...

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Changes in the TCR repertoire of T-cell subsets during culture of cytokine-induced killer cells.

Publication Type: Academic Journal

Source(s): FEBS letters [FEBS Lett] 2022 Oct; Vol. 596 (20), pp. 2696-2705. Date of Electronic Publication: 2022 Oct 02.

Authors:

Abstract: Cytokine-induced killer (CIK) cells are a group of highly heterogeneous T cells expressing diverse T-cell antigen receptors (TCRs), but possessing wide major histocompatibility complex (MHC)-unrestricted antitumour activity, which have been used in the...

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Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease.

Publication Type: Academic Journal

Source(s): Journal of medical virology [J Med Virol] 2022 Sep; Vol. 94 (9), pp. 4088-4096. Date of Electronic Publication: 2022 May 31.

Abstract: Innate and acquired immunity responses are crucial for viral infection elimination. However, genetic variations in coding genes may exacerbate the inflammation or initiate devastating cytokine storms which poses severe respiratory conditions in coronav...

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