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Advanced Search Results For "degradation"

1 - 10 of 93,138 results for
 "degradation"
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ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.

Publication Type: Academic Journal

Source(s): Molecular cell [Mol Cell] 2022 Nov 17; Vol. 82 (22), pp. 4277-4289.e10. Date of Electronic Publication: 2022 Oct 24.

Abstract: The biosynthesis of thousands of proteins requires targeting a signal sequence or transmembrane segment (TM) to the endoplasmic reticulum (ER). These hydrophobic ɑ helices must localize to the appropriate cellular membrane and integrate in the correct ...

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Endoplasmic reticulum-quality control pathway and endoplasmic reticulum-associated degradation mechanism regulate the N-glycoproteins and N-glycan structures in the diatom Phaeodactylum tricornutum.

Publication Type: Academic Journal

Source(s): Microbial cell factories [Microb Cell Fact] 2022 Oct 20; Vol. 21 (1), pp. 219. Date of Electronic Publication: 2022 Oct 20.

Authors:

Abstract: Tunicamycin inhibits the first step of protein N-glycosylation modification. However, the physiological, transcriptomic, and N-glycomic effects of tunicamycin on important marine diatom Phaeodactylum tricornutum are still unknown. In this study, compre...

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Use of predictive scales for pulmonary thromboembolism in an emergency department.

Publication Type: Report

Source(s): Medicina clinica [Med Clin (Barc)] 2022 Nov 25; Vol. 159 (10), pp. 483-485. Date of Electronic Publication: 2022 Jun 06.

Abstract: Background and Objective: Diagnosing pulmonary thromboembolism (PTE) is difficult. Clinical probability scales (CPS) can help. The aim is to find out which one is the best.Patients and Methods: A retrospective cross-sectional single-center study was co...

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4D - Designer D-dimer DVT diagnosis.

Publication Type: Academic Journal

Source(s): VASA. Zeitschrift fur Gefasskrankheiten [Vasa] 2022 Nov; Vol. 51 (6), pp. 389-390.

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The functional importance of VCP to maintaining cellular protein homeostasis.

Publication Type: Academic Journal

Source(s): Biochemical Society transactions [Biochem Soc Trans] 2022 Oct 31; Vol. 50 (5), pp. 1457-1469.

Abstract: The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and c...

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YEARS rule combined with the age-adjusted D-dimer threshold in patients with suspected pulmonary embolism.

Publication Type: Academic Journal

Source(s): Internal and emergency medicine [Intern Emerg Med] 2022 Oct; Vol. 17 (7), pp. 2141-2142. Date of Electronic Publication: 2022 Aug 08.

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The determination of the relationship between p97/VCP, small VCP-interacting protein, two ERAD proteins and steroidogenesis in Leydig cell lines.

Publication Type: Academic Journal

Source(s): Molecular biology reports [Mol Biol Rep] 2022 Oct; Vol. 49 (10), pp. 9159-9170. Date of Electronic Publication: 2022 Aug 07.

Abstract: Background: In recent studies, it was shown that Endoplasmic reticulum-associated degradation (ERAD) is regulated by androgens and small VCP-interacting protein (SVIP) is an ERAD inhibitor. There is no data available about the interactions of ERAD prot...

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Proteasomal degradation of WT proinsulin in pancreatic beta cells.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Oct; Vol. 298 (10), pp. 102406. Date of Electronic Publication: 2022 Aug 19.

Abstract: Preproinsulin entry into the endoplasmic reticulum yields proinsulin, and its subsequent delivery to the distal secretory pathway leads to processing, storage, and secretion of mature insulin. Multiple groups have reported that treatment of pancreatic ...

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N-Glycosylation on Asn50 of SND1 Is Required for Glioma U87 Cell Proliferation and Metastasis.

Publication Type: Academic Journal

Source(s): Journal of immunology research [J Immunol Res] 2022 Sep 29; Vol. 2022, pp. 5239006. Date of Electronic Publication: 2022 Sep 29 (Print Publication: 2022).

Authors:

Abstract: Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multidomain protein, which has gained attention recently due to its positive regulation in several cancer progression and metastatic spread. However, the specific...

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