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Advanced Search Results For "growth"

1 - 10 of 2,065,805 results for
 "growth"
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Pappalysins and Stanniocalcins and Their Relationship With the Peripheral IGF Axis in Newborns and During Development.

Publication Type:Academic Journal

Source(s):The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Sep 28; Vol. 107 (10), pp. 2912-2924.

Abstract:Context: Pappalysins (PAPP-A, PAPP-A2) modulate body growth by increasing insulin-like growth factor I (IGF-I) bioavailability through cleavage of insulin-like growth factor binding proteins (IGFBPs) and are inhibited by stanniocalcins (STC1, STC2). No...

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Placental growth factor stabilizes VEGF receptor-2 protein in retinal pigment epithelial cells by downregulating glycogen synthase kinase 3 activity.

Publication Type:Academic Journal

Source(s):The Journal of biological chemistry [J Biol Chem] 2022 Sep; Vol. 298 (9), pp. 102378. Date of Electronic Publication: 2022 Aug 13.

Abstract:Placental growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF) family of proteins that participate in angiogenesis and vasculogenesis. Anti-VEGF therapy has become the standard treatment for ocular angiogenic disorders in ophth...

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Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability.

Publication Type:Academic Journal

Source(s):American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2022 Sep 01; Vol. 323 (3), pp. E307-E318. Date of Electronic Publication: 2022 Jul 13.

Abstract:Brown bears conserve muscle and bone mass during 6 mo of inactive hibernation. The molecular mechanisms underlying hibernation physiology may have translational relevance for human therapeutics. We hypothesize that protective mechanisms involve increas...

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Vascular endothelial growth factor-C modulates cortical NMDA receptor activity in cortical lesions of young patients and rat model with focal cortical dysplasia.

Publication Type:Academic Journal

Source(s):Brain pathology (Zurich, Switzerland) [Brain Pathol] 2022 Sep; Vol. 32 (5), pp. e13065. Date of Electronic Publication: 2022 Mar 08.

Abstract:Emergence of dysmorphic neurons is the primary pathology in focal cortical dysplasia (FCD) associated pediatric intractable epilepsy; however, the etiologies related to the development and function of dysmorphic neurons are not fully understood. Our pr...

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Increased Colocalization and Interaction Between Decidual Protein Kinase A and Insulin-like Growth Factor-Binding Protein-1 in Intrauterine Growth Restriction.

Publication Type:Academic Journal

Source(s):The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2022 Jul; Vol. 70 (7), pp. 515-530. Date of Electronic Publication: 2022 Jul 08.

Abstract:Increased phosphorylation of decidual insulin-like growth factor-binding protein-1 (IGFBP-1) can contribute to intrauterine growth restriction (IUGR) by decreasing the bioavailability of insulin-like growth factor-1 (IGF-1). However, the molecular mech...

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Mean GH profile is more accurate than single fasting GH in the evaluation of acromegaly disease control during somatostatin receptor ligands therapy.

Publication Type:Academic Journal

Source(s):Journal of endocrinological investigation [J Endocrinol Invest] 2022 Oct; Vol. 45 (10), pp. 1955-1965. Date of Electronic Publication: 2022 Jun 24.

Abstract:Purpose: This study aims to compare the accuracy of mean GH profile (GHP)

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Growth Hormone and Counterregulation in the Pathogenesis of Diabetes.

Publication Type:Academic Journal

Source(s):Current diabetes reports [Curr Diab Rep] 2022 Oct; Vol. 22 (10), pp. 511-524. Date of Electronic Publication: 2022 Aug 24.

Abstract:Purpose of Review: Canonical growth hormone (GH)-dependent signaling is essential for growth and counterregulatory responses to hypoglycemia, but also may contribute to glucose homeostasis (even in the absence of hypoglycemia) via its impact on metabol...

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FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts.

Publication Type:Academic Journal

Source(s):Scientific reports [Sci Rep] 2022 Sep 26; Vol. 12 (1), pp. 16006. Date of Electronic Publication: 2022 Sep 26.

Abstract:The objective of the current study was to examine the effects of fibroblast growth factor-2 (FGF-2) on conjunctival fibrogenesis that was induced by the presence of transforming growth factor-β2 (TGF-β2). Two-dimension (2D) and three-dimension (3D) cul...

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Height outcomes in Korean children with idiopathic short stature receiving growth hormone treatment.

Publication Type:Academic Journal

Source(s):Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Sep 07; Vol. 13, pp. 925102. Date of Electronic Publication: 2022 Sep 07 (Print Publication: 2022).

Abstract:Objectives: Growth hormone (GH) therapy's capacity to increase height velocity and height at the end of the study in children with idiopathic short stature (ISS) is controversial. We aimed to investigate the height standard deviation score (SDS) and he...

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Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study.

Publication Type:Academic Journal

Source(s):BMC endocrine disorders [BMC Endocr Disord] 2022 Aug 09; Vol. 22 (1), pp. 201. Date of Electronic Publication: 2022 Aug 09.

Abstract:Background: To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature.Methods: This real-world study enrolled children with short stature in 19 hospitals throughout China. The...

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