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Advanced Search Results For "immunotherapy"

1 - 10 of 165,162 results for
 "immunotherapy"
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CAR T-cells for colorectal cancer immunotherapy: Ready to go?

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Nov 15; Vol. 13, pp. 978195. Date of Electronic Publication: 2022 Nov 15 (Print Publication: 2022).

Abstract: Chimeric antigen receptor (CAR) T-cells represent a new genetically engineered cell-based immunotherapy tool against cancer. The use of CAR T-cells has revolutionized the therapeutic approach for hematological malignancies. Unfortunately, there is a lo...

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High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity.

Publication Type: Academic Journal

Source(s): Immunity [Immunity] 2022 Oct 11; Vol. 55 (10), pp. 1953-1966.e10. Date of Electronic Publication: 2022 Sep 28.

Abstract: A major challenge in adoptive T cell immunotherapy is the discovery of natural T cell receptors (TCRs) with high activity and specificity to tumor antigens. Engineering synthetic TCRs for increased tumor antigen recognition is complicated by the risk o...

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Correlation of serum vitamin D concentration with humoral-specific IgG2 and IgG4 levels in high responders to immunotherapy with a 300 IR sublingual house dust mite tablet.

Publication Type: Editorial & Opinion

Source(s): Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2022 Oct; Vol. 52 (10), pp. 1219-1224. Date of Electronic Publication: 2022 Jul 27.

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SEAKER cells coordinate cellular immunotherapy with localized chemotherapy.

Publication Type: Academic Journal

Source(s): Trends in pharmacological sciences [Trends Pharmacol Sci] 2022 Oct; Vol. 43 (10), pp. 804-805. Date of Electronic Publication: 2022 Apr 28.

Authors:

Abstract: Tumor antigen escape and T cell dysfunction limit the effectiveness of chimeric antigen receptor (CAR) T cell therapies. To overcome these challenges, Gardner et al. engineered synthetic enzyme-armed killer (SEAKER) cells to coexpress a CAR and a prodr...

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Synthetic Immunotherapy: Programming Immune Cells with Novel and Sophisticated Logic Capabilities.

Publication Type: Academic Journal

Source(s): Transplantation and cellular therapy [Transplant Cell Ther] 2022 Sep; Vol. 28 (9), pp. 560-571. Date of Electronic Publication: 2022 Jun 10.

Abstract: The development of chimeric antigen receptor (CAR) T cells began as a means toward specific yet modular therapies against cancer. Recent advancements in several CAR T cell therapies show the promise of cellular immunotherapy in cancer treatment. CAR T ...

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T-Cell Engagers - Modern Immune-Based Therapies for Multiple Myeloma.

Publication Type: Editorial & Opinion

Source(s): The New England journal of medicine [N Engl J Med] 2022 Aug 11; Vol. 387 (6), pp. 558-561.

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Natural killer cells: the next wave in cancer immunotherapy.

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Jul 27; Vol. 13, pp. 954804. Date of Electronic Publication: 2022 Jul 27 (Print Publication: 2022).

Authors:

Abstract: Immunotherapies focusing on rejuvenating T cell activities, like PD-1/PD-L1 and CTLA-4 blockade, have unprecedentedly revolutionized the landscape of cancer treatment. Yet a previously underexplored component of the immune system - natural killer (NK) ...

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Need for aligning the definition and reporting of cytokine release syndrome (CRS) in immuno-oncology clinical trials.

Publication Type: Academic Journal

Source(s): Cytotherapy [Cytotherapy] 2022 Jul; Vol. 24 (7), pp. 742-749. Date of Electronic Publication: 2022 Feb 23.

Abstract: As cancer immunotherapies continue to expand across all areas of oncology, it is imperative to establish a standardized approach for defining and capturing clinically important toxicities, such as cytokine release syndrome (CRS). In this paper, we prov...

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Stem-like T cells and niches: Implications in human health and disease.

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Aug 17; Vol. 13, pp. 907172. Date of Electronic Publication: 2022 Aug 17 (Print Publication: 2022).

Authors:

Abstract: Recently, accumulating evidence has elucidated the important role of T cells with stem-like characteristics in long-term maintenance of T cell responses and better patient outcomes after immunotherapy. The fate of T SL cells has been correlated with ma...

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Utilizing chemokines in cancer immunotherapy.

Publication Type: Academic Journal

Source(s): Trends in cancer [Trends Cancer] 2022 Aug; Vol. 8 (8), pp. 670-682. Date of Electronic Publication: 2022 Apr 29.

Abstract: Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have demonstrated stunning clinical efficacy in many cancer types. However, most patients do not respond to immunotherapies or relapse after an initial response, stressing ...

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