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Advanced Search Results For "integration"

1 - 10 of 191,884 results for
 "integration"
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Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration.

Publication Type:Academic Journal

Source(s):Journal of virology [J Virol] 2022 Jul 27; Vol. 96 (14), pp. e0067622. Date of Electronic Publication: 2022 Jun 27.

Abstract:Integration of the reverse-transcribed genome is a critical step of the retroviral life cycle. Strand-transfer inhibitors (INSTIs) used for antiretroviral therapy inhibit integration but can lead to resistance mutations in the integrase gene, the enzym...

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Transcription factor Meis1 act as a new regulator of ischemic arrhythmias in mice.

Publication Type:Academic Journal

Source(s):Journal of advanced research [J Adv Res] 2022 Jul; Vol. 39, pp. 275-289. Date of Electronic Publication: 2021 Nov 15.

Abstract:Introduction: The principal voltage-gated Na + channel, Na V 1.5 governs heart excitability and conduction. Na V 1.5 dysregulation is responsible for ventricular arrhythmias and subsequent sudden cardiac death (SCD) in post-infarct hearts. The transcri...

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Elucidating the importance and regulation of key enhancers for human MEIS1 expression.

Publication Type:Academic Journal

Source(s):Leukemia [Leukemia] 2022 Aug; Vol. 36 (8), pp. 1980-1989. Date of Electronic Publication: 2022 May 27.

Abstract:Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset of acute myeloid leukemia (AML). Despite the clinical relevance of MEIS1, its regulation is largely un...

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Community reintegration of people with traumatic brain injury in South Africa.

Publication Type:Academic Journal

Source(s):Brain injury [Brain Inj] 2022 Jul 29; Vol. 36 (9), pp. 1187-1195. Date of Electronic Publication: 2022 Aug 24.

Abstract:Background: Traumatic brain injury (TBI) affects cognitive, behavioral and physical function, influencing community reintegration.Objectives: To describe the level of community reintegration and the associated influencing factors post-TBI in South Afri...

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Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors.

Publication Type:Academic Journal

Source(s):Journal of molecular biology [J Mol Biol] 2022 Jun 15; Vol. 434 (11), pp. 167408. Date of Electronic Publication: 2021 Dec 17.

Abstract:Detecting viral and vector integration events is a key step when investigating interactions between viral and host genomes. This is relevant in several fields, including virology, cancer research and gene therapy. For example, investigating integration...

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Intronic elements associated with insomnia and restless legs syndrome exhibit cell-type-specific epigenetic features contributing to MEIS1 regulation.

Publication Type:Academic Journal

Source(s):Human molecular genetics [Hum Mol Genet] 2022 Jun 04; Vol. 31 (11), pp. 1733-1746.

Abstract:A highly evolutionarily conserved myeloid ecotropic viral integration site 1 (MEIS1) intronic region is strongly associated with restless legs syndrome (RLS) and insomnia. To understand its regulatory function, we dissected the region by analyzing chro...

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Chromatin and viral integration in immunity: The challenge of silencing non-self genes.

Publication Type:Academic Journal

Source(s):Trends in immunology [Trends Immunol] 2022 Jun; Vol. 43 (6), pp. 449-458. Date of Electronic Publication: 2022 Apr 27.

Abstract:Several viruses hide in the genome of their host. To complete their replication cycle, they need to integrate in the form of a provirus and express their genes. In vertebrates, integrated viruses can be silenced by chromatin, implying that some specifi...

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Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer.

Publication Type:Academic Journal

Source(s):Hepatology international [Hepatol Int] 2020 May; Vol. 14 (3), pp. 326-337. Date of Electronic Publication: 2020 Feb 25.

Abstract:Background: Host genome integration of HBV sequence is considered to be significant in HBV antigen expression and the development of hepatocellular carcinoma (HCC).Method: We developed a probe-based capture strategy to enrich integrated HBV DNA for dee...

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Longitudinal Implications of Social Integration for Age and Gender Differences in Late-Life Physical Functioning.

Publication Type:Academic Journal

Source(s):International journal of aging & human development [Int J Aging Hum Dev] 2022 Mar; Vol. 94 (2), pp. 169-192. Date of Electronic Publication: 2020 Dec 14.

Abstract:Social integration has documented benefits for late-life health; yet, little is known about its impacts on trajectories of physical functioning. This study examines age and gender differences in the longitudinal associations between social integration ...

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Myeloid ecotropic viral integration site-1 inhibition promotes apoptosis, suppresses proliferation of acute myeloid leukemia cells, accentuates the effects of anticancer drugs.

Publication Type:Academic Journal

Source(s):Bioengineered [Bioengineered] 2022 Mar; Vol. 13 (3), pp. 5700-5708.

Abstract:To investigate the effects of myeloid ecotropic viral integration site-1 (MEIS1) on the proliferation and apoptosis of acute myeloid leukemia (AML) cells and the anticancer effects of the drug, we screened Kasumi-6, KG-1, and Kasumi-1 cells using quant...

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