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On the relationship of inter-particle cohesiveness and bulk powder behavior: Flowability of pharmaceutical powders.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2016 Sep 10; Vol. 511 (1), pp. 178-189. Date of Electronic Publication: 2016 Jun 25.
Abstract: This study investigates the relationship between particle interactions dominated by the cohesive van der Waals force and powder flowability for materials commonly used by the pharmaceutical industry in oral solid dosage formulation. This study first so...
Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development.
Publication Type: Academic Journal
Source(s): European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2016 Jun 30; Vol. 89, pp. 50-60. Date of Electronic Publication: 2016 Apr 09.
Abstract: Purpose: Inter-subject variability in oral drug absorption is usually reported using bioavailability, which has the components: fraction absorbed (fa), fraction passing the gut wall (fg) and fraction escaping hepatic metabolism (fh). In this study, we ...
Formulation pre-screening of inhalation powders using computational atom-atom systematic search method.
Publication Type: Academic Journal
Source(s): Molecular pharmaceutics [Mol Pharm] 2015 Jan 05; Vol. 12 (1), pp. 18-33. Date of Electronic Publication: 2014 Nov 24.
Abstract: The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes. This study aimed to investigate the functional relevance of synth...
Evaluation of critical process parameters for inter-tablet coating uniformity of active-coated GITS using Terahertz Pulsed Imaging.
Publication Type: Academic Journal
Source(s): European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2014 Oct; Vol. 88 (2), pp. 434-42. Date of Electronic Publication: 2014 Jul 15.
Abstract: The aim of this study was the evaluation of critical process parameters (CPP) for inter-tablet coating uniformity in an active pan coating process using nondestructive Terahertz Pulsed Imaging (TPI). Coating uniformity was assessed by calculating the c...
Robust method optimization strategy-a useful tool for method transfer: the case of SFC.
Publication Type: Academic Journal
Source(s): Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2014 Jan; Vol. 88, pp. 519-24. Date of Electronic Publication: 2013 Oct 12.
Abstract: The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design Space (DS) was introduced in the field of analytica...
Evaluation of genetic fidelity among micropropagated plants of Gloriosa superba L. using DNA-based markers--a potential medicinal plant.
Publication Type: Academic Journal
Source(s): Fitoterapia [Fitoterapia] 2013 Sep; Vol. 89, pp. 265-70. Date of Electronic Publication: 2013 Jun 28.
Abstract: Malabar glory lily (Gloriosa superba L.) is a medicinally potent plant species used for the production of alkaloid colchicine. With ever increasing demand, there is a pressing need to conserve it through biotechnological approaches. A large number of c...
Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method
Publication Type: Academic Journal
Source(s): Fitoterapia. Dec2011, Vol. 82 Issue 8, p1206-1214. 9p.
Abstract: Abstract: In the present study, we are reporting permeability and pharmacokinetics of nobiletin in rat plasma and brain, using a validated reverse phase high performance liquid chromatographic method. Protein precipitation method was used for the extra...