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Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles.

Publication Type: Academic Journal

Source(s): Archives of toxicology [Arch Toxicol] 2017 Jun; Vol. 91 (6), pp. 2315-2330. Date of Electronic Publication: 2016 Dec 10.

Abstract: The rapid development of nanotechnologies and increased production and use of nanomaterials raise concerns about their potential toxic effects for human health and environment. To evaluate the biological effects of nanomaterials, a set of reliable and ...

On the relationship of inter-particle cohesiveness and bulk powder behavior: Flowability of pharmaceutical powders.

Publication Type: Academic Journal

Source(s): International journal of pharmaceutics [Int J Pharm] 2016 Sep 10; Vol. 511 (1), pp. 178-189. Date of Electronic Publication: 2016 Jun 25.

Abstract: This study investigates the relationship between particle interactions dominated by the cohesive van der Waals force and powder flowability for materials commonly used by the pharmaceutical industry in oral solid dosage formulation. This study first so...

Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.

Publication Type: Academic Journal

Source(s): Archives of toxicology [Arch Toxicol] 2016 Sep; Vol. 90 (9), pp. 2215-2229. Date of Electronic Publication: 2015 Nov 02.

Abstract: The assessment of the carcinogenic potential of chemicals with alternative, human-based in vitro systems has become a major goal of toxicogenomics. The central read-out of these assays is the transcriptome, and while many studies exist that explored th...

Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development.

Publication Type: Academic Journal

Source(s): European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2016 Jun 30; Vol. 89, pp. 50-60. Date of Electronic Publication: 2016 Apr 09.

Abstract: Purpose: Inter-subject variability in oral drug absorption is usually reported using bioavailability, which has the components: fraction absorbed (fa), fraction passing the gut wall (fg) and fraction escaping hepatic metabolism (fh). In this study, we ...

Intravenous administration of silver nanoparticles causes organ toxicity through intracellular ROS-related loss of inter-endothelial junction.

Publication Type: Academic Journal

Source(s): Particle and fibre toxicology [Part Fibre Toxicol] 2016 Apr 29; Vol. 13, pp. 21. Date of Electronic Publication: 2016 Apr 29.

Abstract: Background: Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation in multiple organs, with notable prominence in liver, lungs, and kidneys. However, how AgNPs transport through blood vesicular system...

Ecotoxicogenomics: Microarray interlaboratory comparability.

Publication Type: Academic Journal

Source(s): Chemosphere [Chemosphere] 2016 Feb; Vol. 144, pp. 193-200. Date of Electronic Publication: 2015 Sep 10.

Abstract: Transcriptomic analysis can complement traditional ecotoxicology data by providing mechanistic insight, and by identifying sub-lethal organismal responses and contaminant classes underlying observed toxicity. Before transcriptomic information can be us...

Formulation pre-screening of inhalation powders using computational atom-atom systematic search method.

Publication Type: Academic Journal

Source(s): Molecular pharmaceutics [Mol Pharm] 2015 Jan 05; Vol. 12 (1), pp. 18-33. Date of Electronic Publication: 2014 Nov 24.

Abstract: The synthonic modeling approach provides a molecule-centered understanding of the surface properties of crystals. It has been applied extensively to understand crystallization processes. This study aimed to investigate the functional relevance of synth...

Evaluation of critical process parameters for inter-tablet coating uniformity of active-coated GITS using Terahertz Pulsed Imaging.

Publication Type: Academic Journal

Source(s): European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2014 Oct; Vol. 88 (2), pp. 434-42. Date of Electronic Publication: 2014 Jul 15.

Abstract: The aim of this study was the evaluation of critical process parameters (CPP) for inter-tablet coating uniformity in an active pan coating process using nondestructive Terahertz Pulsed Imaging (TPI). Coating uniformity was assessed by calculating the c...

Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings.

Publication Type: Academic Journal

Source(s): International journal of nanomedicine [Int J Nanomedicine] 2014 Mar 08; Vol. 9, pp. 1243-60. Date of Electronic Publication: 2014 Mar 08 (Print Publication: 2014).

Authors:

Abstract: The process in which nanostructured surfaces mediate cell adhesion is not well understood, and may be indirect (via protein adsorption) or direct. We prepared Sr-doped hydroxyapatite (Sr1-HA) 3D nanorods (with interrod spacing of 67.3 ± 3.8, 95.7 ± 4.2...

Robust method optimization strategy-a useful tool for method transfer: the case of SFC.

Publication Type: Academic Journal

Source(s): Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2014 Jan; Vol. 88, pp. 519-24. Date of Electronic Publication: 2013 Oct 12.

Abstract: The concept of Quality by Design (QbD) is now well established in pharmaceutical industry and should be applied to the development of any analytical methods. In this context, the key concept of Design Space (DS) was introduced in the field of analytica...

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