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A Camptothetin Analog, Topotecan, Promotes HIV Latency via Interference with HIV Transcription and RNA Splicing.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Feb 28; Vol. 97 (2), pp. e0163022. Date of Electronic Publication: 2023 Jan 31.
Abstract: Low level HIV transcription during modern antiretroviral therapy (ART) in persons with HIV is linked to residual inflammation and associated diseases, like cardiovascular disease and cancer. The "block and lock" approach to hold HIV in a state of deep ...
Enhanced Transcriptional Strength of HIV-1 Subtype C Minimizes Gene Expression Noise and Confers Stability to the Viral Latent State.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Jan 31; Vol. 97 (1), pp. e0137622. Date of Electronic Publication: 2022 Dec 19.
Abstract: Stochastic fluctuations in gene expression emanating from the HIV-1 long terminal repeat (LTR), amplified by the Tat positive feedback circuit, determine the choice between viral infection fates: active transcription (ON) or transcriptional silence (OF...
Melanopic irradiance defines the impact of evening display light on sleep latency, melatonin and alertness.
Publication Type: Academic Journal
Source(s): Communications biology [Commun Biol] 2023 Mar 01; Vol. 6 (1), pp. 228. Date of Electronic Publication: 2023 Mar 01.
Abstract: Evening light-emitting visual displays may disrupt sleep, suppress melatonin and increase alertness. Here, we control melanopic irradiance independent of display luminance and colour, in 72 healthy males 4 h before habitual bedtime and expose each of t...
HSV-1 LAT Promoter Deletion Viruses Exhibit Strain-Specific and LAT-Dependent Epigenetic Regulation of Latent Viral Genomes in Human Neurons.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Feb 28; Vol. 97 (2), pp. e0193522. Date of Electronic Publication: 2023 Feb 01.
Abstract: Herpes simplex virus 1 (HSV-1) establishes latency in neurons and expresses long noncoding RNAs termed the latency-associated transcripts (LATs). Two previous studies using HSV-1 recombinants containing deletions in the LAT promoter revealed opposing e...
HIV silencing and cell survival signatures in infected T cell reservoirs.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2023 Feb; Vol. 614 (7947), pp. 318-325. Date of Electronic Publication: 2023 Jan 04.
Abstract: Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier to HIV cure 1-3 , but the infeasibility of isolating and characterizing these cells in their natural state has led to uncertainty about whether they possess d...
Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Deception Study.
Publication Type: Academic Journal
Source(s): Medicine and science in sports and exercise [Med Sci Sports Exerc] 2023 Feb 01; Vol. 55 (2), pp. 289-300. Date of Electronic Publication: 2022 Sep 09.
Abstract: Purpose: This study aimed to test the hypothesis that a novel nutritional blend composed of tryptophan, glycine, magnesium, tart cherry powder, and l -theanine enhances subjective and objective measures of sleep during free living conditions.Methods: I...
Phenotypic signatures of immune selection in HIV-1 reservoir cells.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2023 Feb; Vol. 614 (7947), pp. 309-317. Date of Electronic Publication: 2023 Jan 04.
Abstract: Human immunodeficiency virus 1 (HIV-1) reservoir cells persist lifelong despite antiretroviral treatment 1,2 but may be vulnerable to host immune responses that could be exploited in strategies to cure HIV-1. Here we used a single-cell, next-generation...
Inhibition of the TRIM24 bromodomain reactivates latent HIV-1.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Jan 11; Vol. 13 (1), pp. 556. Date of Electronic Publication: 2023 Jan 11.
Abstract: Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter. We recently discove...
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.
Publication Type: Academic Journal
Source(s): Viruses [Viruses] 2022 Oct 18; Vol. 14 (10). Date of Electronic Publication: 2022 Oct 18.
Abstract: Immune cell state alterations rewire HIV-1 gene expression, thereby influencing viral latency and reactivation, but the mechanisms are still unfolding. Here, using a screen approach on CD4 + T cell models of HIV-1 latency, we revealed Small Molecule Re...
Medicinal Chemistry of Anti-HIV-1 Latency Chemotherapeutics: Biotargets, Binding Modes and Structure-Activity Relationship Investigation.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Dec 20; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 20.
Abstract: The existence of latent viral reservoirs (LVRs), also called latent cells, has long been an acknowledged stubborn hurdle for effective treatment of HIV-1/AIDS. This stable and heterogeneous reservoir, which mainly exists in resting memory CD4 + T cells...