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Phase II clinical trial to study the safety and efficacy of combined S-1 + oxaliplatin therapy as neoadjuvant chemotherapy for locally advanced gastric cancer in older patients.
Publication Type: Academic Journal
Source(s): International journal of clinical oncology [Int J Clin Oncol] 2023 Sep; Vol. 28 (9), pp. 1166-1175. Date of Electronic Publication: 2023 Jun 27.
Abstract: Background: Gastrectomy with D2 dissection and adjuvant chemotherapy is the standard treatment for locally advanced gastric cancer (LAGC) in Asia. However, administering chemotherapy with sufficient intensity after gastrectomy is challenging. Several t...
Differential immunomodulatory effects of epirubicin/cyclophosphamide and docetaxel in breast cancer patients.
Publication Type: Academic Journal
Source(s): Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Nov 14; Vol. 42 (1), pp. 300. Date of Electronic Publication: 2023 Nov 14.
Abstract: Background: Epirubicin/cyclophosphamide (EC) and docetaxel (D) are commonly used in a sequential regimen in the neoadjuvant treatment of early, high-risk or locally advanced breast cancer (BC). Novel approaches to increase the response rate combine thi...
Optimal number of neoadjuvant chemotherapy cycles prior to interval debulking surgery in advanced epithelial ovarian cancer: a systematic review and meta-analysis of progression-free survival and overall survival.
Publication Type: Academic Journal
Source(s): Journal of gynecologic oncology [J Gynecol Oncol] 2023 Nov; Vol. 34 (6), pp. e82. Date of Electronic Publication: 2023 Sep 05.
Abstract: Objective: Neoadjuvant chemotherapy (NACT) represents a treatment option in patients with advanced epithelial ovarian cancer (AEOC) who are not good candidates for primary debulking surgery. Usually, 3 cycles of chemotherapy before surgery have been co...
Concurrent chemoradiotherapy with or without neoadjuvant chemotherapy in pediatric patients with stage III-IVa nasopharyngeal carcinoma: a real-world propensity score-matched cohort study.
Publication Type: Academic Journal
Source(s): Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Oct; Vol. 149 (13), pp. 11929-11940. Date of Electronic Publication: 2023 Jul 07.
Abstract: Objectives: To compare neoadjuvant chemotherapy (NAC) plus concurrent chemoradiotherapy (CCRT) to CCRT alone in children and adolescents (age ≤ 18 years) with locoregionally advanced nasopharyngeal carcinoma (CA-LANPC, stage III-IVA).Materials and Meth...
Cell-free DNA Methylation as a Predictive Biomarker of Response to Neoadjuvant Chemotherapy for Patients with Muscle-invasive Bladder Cancer in SWOG S1314.
Publication Type: Academic Journal
Source(s): European urology oncology [Eur Urol Oncol] 2023 Oct; Vol. 6 (5), pp. 516-524. Date of Electronic Publication: 2023 Apr 20.
Abstract: Background: Neoadjuvant chemotherapy (NAC) is the standard of care in muscle-invasive bladder cancer (MIBC). However, treatment is intense, and the overall benefit is small, necessitating effective biomarkers to identify patients who will benefit most....
Neoadjuvant chemotherapy in older patients with gastric cancer undergoing surgery: a population-based cohort study.
Publication Type: Academic Journal
Source(s): Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association [Gastric Cancer] 2023 Sep; Vol. 26 (5), pp. 763-774. Date of Electronic Publication: 2023 Jun 07.
Abstract: Background: In trials evaluating perioperative chemotherapy for gastric cancer, which serve as the basis for treatment guidelines, patients are selected. The generalizability of these trial findings to older patients is uncertain.Methods: This populati...
Predicting conversion surgery in patients with locally advanced pancreatic cancer after modified FOLFIRINOX treatment.
Publication Type: Academic Journal
Source(s): Asian journal of surgery [Asian J Surg] 2023 Sep; Vol. 46 (9), pp. 3542-3548. Date of Electronic Publication: 2023 Apr 20.
Abstract: Background: /Objective: FOLFIRINOX therapy (FFX) for locally advanced pancreatic cancer (LAPC) is increasingly recognized as a potent neoadjuvant therapy that enables transition to conversion surgery (CS). However, predictors of CS achievement after ch...
Timing of interval debulking surgery and postoperative chemotherapy after neoadjuvant chemotherapy in advanced epithelial ovarian cancer: a multicenter real-world study.
Publication Type: Academic Journal
Source(s): Journal of ovarian research [J Ovarian Res] 2023 Jun 27; Vol. 16 (1), pp. 121. Date of Electronic Publication: 2023 Jun 27.
Abstract: Background: To investigate the prognostic relevance of the time to interval debulking surgery (TTS) and the time to postoperative adjuvant chemotherapy (TTC) after the completion of neoadjuvant chemotherapy (NACT).Methods: A retrospective real-word stu...
Neoadjuvant chemotherapy followed by interval debulking surgery for advanced epithelial ovarian cancer: GOTIC-019 study.
Publication Type: Academic Journal
Source(s): International journal of clinical oncology [Int J Clin Oncol] 2023 Jun; Vol. 28 (6), pp. 804-815. Date of Electronic Publication: 2023 May 04.
Abstract: Introduction: Three randomized controlled trials have resulted in extremely extensive application of the strategy of using neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS) for patients with advanced epithelial ovarian cancer ...
Current neoadjuvant therapy for operable locally advanced esophageal cancer.
Publication Type: Academic Journal
Source(s): Medical oncology (Northwood, London, England) [Med Oncol] 2023 Jul 27; Vol. 40 (9), pp. 252. Date of Electronic Publication: 2023 Jul 27.
Abstract: Locally advanced esophageal cancer has a poor prognosis, while an increasing number of patients are diagnosed with that. Neoadjuvant therapy has become a hot topic in treating locally advanced esophageal cancer to improve its survival benefit. The effi...