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Advanced Search Results For "proteomics"

1 - 10 of 138,210 results for
 "proteomics"
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Addressing the Protease Bias in Quantitative Proteomics.

Publication Type: Academic Journal

Source(s): Journal of proteome research [J Proteome Res] 2022 Oct 07; Vol. 21 (10), pp. 2526-2534. Date of Electronic Publication: 2022 Aug 31.

Abstract: Protein quantification strategies using multiple proteases have been shown to deliver poor interprotease accuracy in label-free mass spectrometry experiments. By utilizing six different proteases with different cleavage sites, this study explores the p...

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Coupling High-Field Asymmetric Ion Mobility Spectrometry with Capillary Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry Improves Protein Identifications in Bottom-Up Proteomic Analysis of Low Nanogram Samples.

Publication Type: Academic Journal

Source(s): Journal of proteome research [J Proteome Res] 2022 Oct 07; Vol. 21 (10), pp. 2453-2461. Date of Electronic Publication: 2022 Sep 16.

Abstract: In this work, we pioneered the assessment of coupling high-field asymmetric waveform ion mobility spectrometry (FAIMS) with ultrasensitive capillary electrophoresis hyphenated with tandem mass spectrometry (CE-MS/MS) to achieve deeper proteome coverage...

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Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.

Publication Type: Academic Journal

Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Oct 04; Vol. 119 (40), pp. e2117175119. Date of Electronic Publication: 2022 Sep 30.

Abstract: Protein-protein interactions (PPIs) represent the main mode of the proteome organization in the cell. In the last decade, several large-scale representations of PPI networks have captured generic aspects of the functional organization of network compon...

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Validation of Top-Down Proteomics Data by Bottom-Up-Based N-Terminomics Reveals Pitfalls in Top-Down-Based Terminomics Workflows.

Publication Type: Academic Journal

Source(s): Journal of proteome research [J Proteome Res] 2022 Sep 02; Vol. 21 (9), pp. 2185-2196. Date of Electronic Publication: 2022 Aug 16.

Abstract: Bottom-up proteomics (BUP)-based N-terminomics techniques have become standard to identify protein N-termini. While these methods rely on the identification of N-terminal peptides only, top-down proteomics (TDP) comes with the promise to provide additi...

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Ecological Monitoring and Omics: A Comprehensive Comparison of Workflows for Mass Spectrometry-Based Quantitative Proteomics of Fish ( Labeo rohita ) Liver Tissue.

Publication Type: Academic Journal

Source(s): Omics : a journal of integrative biology [OMICS] 2022 Sep; Vol. 26 (9), pp. 489-503. Date of Electronic Publication: 2022 Aug 26.

Abstract: Introduction: The liver is highly sensitive to the environmental factors. Liver tissue, particularly from fish, is often used as a biological target in ecological monitoring, disease research, and stress response studies. Labeo rohita (rohu) i...

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Subcellular redox responses reveal different Cu-dependent antioxidant defenses between mitochondria and cytosol.

Publication Type: Academic Journal

Source(s): Metallomics : integrated biometal science [Metallomics] 2022 Nov 24; Vol. 14 (11).

Authors:

Abstract: Excess intracellular Cu perturbs cellular redox balance and thus causes diseases. However, the relationship between cellular redox status and Cu homeostasis and how such an interplay is coordinated within cellular compartments has not yet been well est...

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Comparative proteomic analysis of mustard lung as a complicated disease using systems biology approach.

Publication Type: Academic Journal

Source(s): BMC pulmonary medicine [BMC Pulm Med] 2022 Nov 23; Vol. 22 (1), pp. 437. Date of Electronic Publication: 2022 Nov 23.

Abstract: During Iraq-Iran conflict, chemical weapons, particularly SM gas, were used numerous times, whose aftereffects are still present. This study aimed to compare serum proteome in the chronic ML (n = 10) and HC (n = 10). TMT label-based quantitative proteo...

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Differential Expression of Serum Proteins in Chronic Obstructive Pulmonary Disease Assessed Using Label-Free Proteomics and Bioinformatics Analyses.

Publication Type: Academic Journal

Source(s): International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2022 Nov 15; Vol. 17, pp. 2871-2891. Date of Electronic Publication: 2022 Nov 15 (Print Publication: 2022).

Authors:

Abstract: Purpose: As a common respiratory disease, chronic obstructive pulmonary disease (COPD) has a high morbidity and mortality. Current clinical therapies are not ideal and do not improve lung function or long-term life quality. It is very important to find...

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Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa.

Publication Type: Academic Journal

Source(s): Cell reports [Cell Rep] 2022 Nov 15; Vol. 41 (7), pp. 111655.

Abstract: Spermatozoa acquire fertilization potential during passage through a highly specialized region of the extratesticular ductal system known as the epididymis. In the absence of de novo gene transcription or protein translation, this functional transforma...

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A protein identification method for proteomics using amino acid composition analysis with IoT-based remote control.

Publication Type: Academic Journal

Source(s): Analytical biochemistry [Anal Biochem] 2022 Nov 15; Vol. 657, pp. 114904. Date of Electronic Publication: 2022 Sep 21.

Abstract: In the present study, we developed a protein identification method using low-cost and easy-to-operate amino acid composition analysis. The identification program automatically compares the quantitative result for each amino acid concentration obtained ...

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