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Advanced Search Results For "regulation"

1 - 10 of 1,358,751 results for
 "regulation"
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Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.

Publication Type:Academic Journal

Source(s):Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2022 Sep; Vol. 251 (9), pp. 1439-1455. Date of Electronic Publication: 2021 Nov 20.

Abstract:Background: The phalanges are the final skeletal elements to form in the vertebrate limb and their identity is regulated by signaling at the phalanx forming region (PFR) located at the tip of the developing digit ray. Here, we seek to explore the relat...

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First glimpse of enhancers in gene regulation.

Publication Type:Academic Journal

Source(s):Nature reviews. Genetics [Nat Rev Genet] 2022 Sep; Vol. 23 (9), pp. 522-523.

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Modeling reveals posttranscriptional regulation of GA metabolism enzymes in response to drought and cold.

Publication Type:Academic Journal

Source(s):Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 02; Vol. 119 (31), pp. e2121288119. Date of Electronic Publication: 2022 Jul 25.

Abstract:The hormone gibberellin (GA) controls plant growth and regulates growth responses to environmental stress. In monocotyledonous leaves, GA controls growth by regulating division-zone size. We used a systems approach to investigate the establishment of t...

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Silencing long non-coding RNA LINC00960 inhibits osteosarcoma proliferation by sponging miR-107 to downregulate SALL4.

Publication Type:Academic Journal

Source(s):Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Feb 12; Vol. 592, pp. 99-105. Date of Electronic Publication: 2022 Jan 11.

Abstract:long non-coding RNAs (lncRNAs), as tumor suppressors or oncogenes, have been identified to play key roles in tumorigenesis. The present study explored the roles and potential mechanisms of LINC00960 in osteosarcoma (OS). In vitro study showed that sile...

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Upregulation of proto-oncogene ski by thyroid hormone in the intestine and tail during Xenopus metamorphosis.

Publication Type:Academic Journal

Source(s):General and comparative endocrinology [Gen Comp Endocrinol] 2022 Nov 01; Vol. 328, pp. 114102. Date of Electronic Publication: 2022 Aug 06.

Abstract:Thyroid hormone (T3) is important for adult organ function and vertebrate development, particularly during the postembryonic period when many organs develop/mature into their adult forms. Amphibian metamorphosis is totally dependent on T3 and can be ea...

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E2F5 promotes proliferation and invasion of gastric cancer through directly upregulating UBE2T transcription.

Publication Type:Academic Journal

Source(s):Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2022 Jul; Vol. 54 (7), pp. 937-945. Date of Electronic Publication: 2021 Sep 26.

Abstract:The underlying mechanisms of E2F5 upregulation and its pro-tumor functions have not been elucidated in gastric cancer (GC). Here, the expression, prognostic value, mutation status, and promoter methylation of E2F5 were evaluated. The effects of E2F5 de...

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Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells.

Publication Type:Academic Journal

Source(s):Bioengineered [Bioengineered] 2021 Dec; Vol. 12 (1), pp. 1126-1137.

Abstract:Diabetic osteoporosis (DOP) is a chronic complication of diabetes in the skeletal system. High level of miR-340-5p may be harmful to the bone formation. In this study, the DOP model of rats was successfully established via streptozotocin (STZ) and ovar...

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The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter.

Publication Type:Academic Journal

Source(s):Journal of virology [J Virol] 2022 Jul 27; Vol. 96 (14), pp. e0065222. Date of Electronic Publication: 2022 Jun 29.

Abstract:Human mannose receptor 1 (MRC1) is a cell surface receptor expressed in macrophages and other myeloid cells that inhibits human immunodeficiency virus type 1 (HIV-1) particle release by tethering virions to producer cell membranes. HIV-1 counteracts MR...

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Downregulation of C12orf75 gene inhibits migration and invasion of liver cancer cell via suppressing the Wnt/β-catenin signaling pathway in vitro.

Publication Type:Academic Journal

Source(s):Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jul 23; Vol. 614, pp. 92-99. Date of Electronic Publication: 2022 May 10.

Abstract:Hepatic carcinoma (HCC) is the second leading cause of death in cancer patients, and its incidence is on the rise. The prerequisite for the deterioration of liver cancer is the malignant migration and invasion of cancer cells, and in this study the C12...

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Super-enhancer hypermutation alters oncogene expression in B cell lymphoma.

Publication Type:Academic Journal

Source(s):Nature [Nature] 2022 Jul; Vol. 607 (7920), pp. 808-815. Date of Electronic Publication: 2022 Jul 06.

Abstract:Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma and remains incurable in around 40% of patients. Efforts to sequence the coding genome identified several genes and pathways that are altered in this disease, includin...

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