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Advanced Search Results For "transformation"

1 - 10 of 271,991 results for
 "transformation"
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Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation.

Publication Type:Academic Journal

Source(s):International journal of molecular sciences [Int J Mol Sci] 2022 Jul 09; Vol. 23 (14). Date of Electronic Publication: 2022 Jul 09.

Abstract:The Transformics Assay is an in vitro test which combines the BALB/c 3T3 Cell Transformation Assay (CTA) with microarray transcriptomics. It has been shown to improve upon the mechanistic understanding of the CTA, helping to identify mechanisms of acti...

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Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells.

Publication Type:Academic Journal

Source(s):BMC cancer [BMC Cancer] 2022 Sep 10; Vol. 22 (1), pp. 969. Date of Electronic Publication: 2022 Sep 10.

Abstract:Background: Lysophosphatidic acid receptor 3 (LPAR3) is coupled to Gα i/o and Gα 11/q signaling. Previously, we reported that LPAR3 is highly methylated in carcinogen-induced transformed cells. Here, we demonstrate that LPAR3 exhibits malignant transfo...

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Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53.

Publication Type:Academic Journal

Source(s):Chemical research in toxicology [Chem Res Toxicol] 2022 Sep 19; Vol. 35 (9), pp. 1598-1603. Date of Electronic Publication: 2022 Aug 26.

Abstract:Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant p53 has attracted attention for cancer therapy. We isolated colletofragarone A...

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Metabolic reprogramming: a bridge between aging and tumorigenesis.

Publication Type:Academic Journal

Source(s):Molecular oncology [Mol Oncol] 2022 Sep; Vol. 16 (18), pp. 3295-3318. Date of Electronic Publication: 2022 Jun 19.

Abstract:Aging is the most robust risk factor for cancer development, with more than 60% of cancers occurring in those aged 60 and above. However, how aging and tumorigenesis are intertwined is poorly understood and a matter of significant debate. Metabolic cha...

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Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation.

Publication Type:Academic Journal

Source(s):Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 09; Vol. 119 (32), pp. e2201493119. Date of Electronic Publication: 2022 Aug 03.

Abstract:Understanding the mechanisms promoting chromosomal translocations of the rearranging receptor loci in leukemia and lymphoma remains incomplete. Here we show that leukemias induced by aberrant activation of β-catenin in thymocytes, which bear recurrent ...

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Ultrastructural characteristics of finger-like membrane protrusions in cell competition.

Publication Type:Academic Journal

Source(s):Microscopy (Oxford, England) [Microscopy (Oxf)] 2022 Aug 01; Vol. 71 (4), pp. 195-205.

Abstract:A small number of oncogenic mutated cells sporadically arise within the epithelial monolayer. Newly emerging Ras- or Src-transformed epithelial cells are often apically eliminated during competitive interactions between normal and transformed cells. Ou...

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Direct visualization of sequence-specific DNA binding by gonococcal type IV pili.

Publication Type:Academic Journal

Source(s):Microbiology (Reading, England) [Microbiology (Reading)] 2022 Aug; Vol. 168 (8).

Abstract:Neisseria gonorrhoeae , the causative agent of gonorrhoea, is a major burden on global healthcare systems, with an estimated ~80-90 million new global cases annually. This burden is exacerbated by increasing levels of antimicrobial resistance, which ha...

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A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies.

Publication Type:Academic Journal

Source(s):Cells [Cells] 2022 Jul 22; Vol. 11 (15). Date of Electronic Publication: 2022 Jul 22.

Abstract:Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells. The impact of intra-tumor cellular heterogeneity using a label-free...

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[About some theories of oncogenesis].

Publication Type:Editorial & Opinion

Source(s):Bulletin du cancer [Bull Cancer] 2022 Jul-Aug; Vol. 109 (7-8), pp. 742-747. Date of Electronic Publication: 2022 Jun 02.

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Competence pili in Streptococcus pneumoniae are highly dynamic structures that retract to promote DNA uptake.

Publication Type:Academic Journal

Source(s):Molecular microbiology [Mol Microbiol] 2021 Aug; Vol. 116 (2), pp. 381-396. Date of Electronic Publication: 2021 Apr 16.

Abstract:The competence pili of transformable Gram-positive species are phylogenetically related to the diverse and widespread class of extracellular filamentous organelles known as type IV pili. In Gram-negative bacteria, type IV pili act through dynamic cycle...

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