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Identification of inter-particular forces by atomic force microscopy and how they relate to powder rheological properties measured in shearing tests.
Publication Type: Academic Journal
Source(s): Powder Technology. Nov2015, Vol. 284, p396-402. 7p.
Abstract: In this study, we used atomic force microscopy (AFM) to measure and identify the nature of the forces acting between single pharmaceutical powder particles, namely a crystalline and a semi-crystalline form of lactose. The experiments done at different ...
Nanoparticle Additivation Effects on Laser Powder Bed Fusion of Metals and Polymers—A Theoretical Concept for an Inter-Laboratory Study Design All Along the Process Chain, Including Research Data Management.
Publication Type: Academic Journal
Source(s): Materials (1996-1944). Sep2021, Vol. 14 Issue 17, p4892. 1p.
Abstract: In recent years, the application field of laser powder bed fusion of metals and polymers extends through an increasing variability of powder compositions in the market. New powder formulations such as nanoparticle (NP) additivated powder feedstocks are...
Quantifying stress-induced anisotropy using inter-void constrictions.
Publication Type: Academic Journal
Source(s): Géotechnique. Jan2013, Vol. 63 Issue 1, p85-91. 7p.
Abstract: In particulate geomechanics it is common to quantify fabric anisotropy using contact and particle orientations. Measurement of void anisotropy is less common, most likely owing to the difficulties associated with defining individual voids. Here a Delau...
Improving deposition efficiency and inter-particle bonding of cold sprayed Cu through removing the surficial oxide scale of the feedstock powder.
Publication Type: Academic Journal
Source(s): Surface & Coatings Technology. Feb2021, Vol. 407, pN.PAG-N.PAG. 1p.
Abstract: In cold spray, surficial oxide scale of the feedstock powder not only reduces the deposition efficiency of spraying powder, but also deteriorates the properties of the deposit due to its influence on inter-particle bonding. To simultaneously improve th...
Estimating inter-patient variability of dispersion in dry powder inhalers using CFD-DEM simulations.
Publication Type: Academic Journal
Source(s): European Journal of Pharmaceutical Sciences. Jan2021, Vol. 156, pN.PAG-N.PAG. 1p.
Abstract: Drug delivery from a capsule-based dry powder inhaler depends on the inhaler's design, the drug's formulation, and the inhalation maneuver. The latter affects both the air flow and the capsule motion in the inhaler. It is well known that patient-to-pat...
Inter-Allelic Prion Propagation Reveals Conformational Relationships among a Multitude of [PSI] Strains.
Publication Type: Academic Journal
Source(s): PLoS Genetics. Sep2011, Vol. 7 Issue 9, Special section p1-9. 9p.
Abstract: Immense diversity of prion strains is observed, but its underlying mechanism is less clear. Three [PSI] prion strains-named VH, VK, and VL-were previously isolated in the wild-type yeast genetic background. Here we report the generation and characteriz...
Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET
Publication Type: Academic Journal
Source(s): NeuroImage. Apr2011, Vol. 55 Issue 3, p933-941. 9p.
Abstract: Abstract: A major challenge in positron emission tomography (PET) amyloid imaging studies of Alzheimer''s disease (AD) is the reliable detection of early amyloid deposition in human brain. Manual region-of-interest (ROI) delineation on structural magne...
Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness.
Publication Type: Academic Journal
Source(s): Journal of Adhesion Science & Technology. 2011, Vol. 25 Issue 4/5, p367-384. 18p. 1 Black and White Photograph, 3 Charts, 7 Graphs.
Abstract: Fine powder flow is a topic of great interest to industry, in particular for the pharmaceutical industry; a major concern being their poor flow behavior due to high cohesion. In this study, cohesion reduction, produced via surface modification, at the ...
Inter-laboratory variation in cerebrospinal fluid biomarkers for Alzheimer's disease: united we stand, divided we fall.
Publication Type: Academic Journal
Source(s): Clinical Chemistry & Laboratory Medicine. May2010, Vol. 48 Issue 5, p603-607. 5p.
Abstract: Several drug candidates for Alzheimer's disease are being evaluated in clinical trials, with the goal of finding a drug with disease-modifying effects. When such a drug finally reaches the market, there will be a demand for accurate diagnostic tools us...
Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form.
Publication Type: Academic Journal
Source(s): Amyloid. Dec2008, Vol. 15 Issue 4, p240-245. 6p. 1 Diagram, 2 Graphs.
Abstract: Familial amyloidotic polyneuropathy (FAP) is linked to destabilising point mutations in the human plasma protein transthyretin (TTR). Consistent with similar amyloid disorders, low molecular weight TTR oligomers have been shown to exert the major cytot...