Advanced Search Results For "inter-"
Tackling intra- and inter-tumor heterogeneity to combat triple negative breast cancer.
Publication Type: Academic Journal
Source(s): Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2017 Jun 01; Vol. 22 (9), pp. 1549-1580. Date of Electronic Publication: 2017 Jun 01.
Abstract: Rampant inter-patient and intra-tumor heterogeneity present formidable challenges in the clinical management of triple-negative breast cancer (TNBC) and mandate a "divide-and-conquer" approach wherein deep biomarker profiling drives patient segmentatio...
Inter- and intra-species variation in genome-wide gene expression of Drosophila in response to parasitoid wasp attack.
Publication Type: Academic Journal
Source(s): BMC genomics [BMC Genomics] 2017 Apr 27; Vol. 18 (1), pp. 331. Date of Electronic Publication: 2017 Apr 27.
Abstract: Background: Parasitoid resistance in Drosophila varies considerably, among and within species. An immune response, lamellocyte-mediated encapsulation, evolved in a subclade of Drosophila and was subsequently lost in at least one species within this sub...
Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.
Publication Type: Academic Journal
Source(s): Archives of toxicology [Arch Toxicol] 2016 Sep; Vol. 90 (9), pp. 2215-2229. Date of Electronic Publication: 2015 Nov 02.
Abstract: The assessment of the carcinogenic potential of chemicals with alternative, human-based in vitro systems has become a major goal of toxicogenomics. The central read-out of these assays is the transcriptome, and while many studies exist that explored th...
Investigating inter-chromosomal regulatory relationships through a comprehensive meta-analysis of matched copy number and transcriptomics data sets.
Publication Type: Academic Journal
Source(s): BMC genomics [BMC Genomics] 2015 Nov 18; Vol. 16, pp. 967. Date of Electronic Publication: 2015 Nov 18.
Abstract: Background: Gene regulatory relationships can be inferred using matched array comparative genomics and transcriptomics data sets from cancer samples. The way in which copy numbers of genes in cancer samples are often greatly disrupted works like a natu...
Wide Inter-institutional Variation in Performance of a Molecular Classifier for Indeterminate Thyroid Nodules.
Publication Type: Academic Journal
Source(s): Annals of surgical oncology [Ann Surg Oncol] 2015 Nov; Vol. 22 (12), pp. 3996-4001. Date of Electronic Publication: 2015 Apr 11.
Abstract: Background: The Afirma gene expression classifier (GEC) is used to assess malignancy risk in indeterminate thyroid nodules (ITNs) classified as Bethesda category III/IV. Our objective was to analyze GEC performance at two institutions with high thyroid...
Transcriptome sequencing in prostate cancer identifies inter-tumor heterogeneity.
Publication Type: Academic Journal
Source(s): Asian journal of andrology [Asian J Androl] 2015 May-Jun; Vol. 17 (3), pp. 435-6.
Abstract: Given the dearth of gene mutations in prostate cancer, [1] ,[2] it is likely that genomic rearrangements play a significant role in the evolution of prostate cancer. However, in the search for recurrent genomic alterations, "private alterations" have r...
Inter-species prediction of protein phosphorylation in the sbv IMPROVER species translation challenge.
Publication Type: Academic Journal
Source(s): Bioinformatics (Oxford, England) [Bioinformatics] 2015 Feb 15; Vol. 31 (4), pp. 453-61. Date of Electronic Publication: 2014 Jul 03.
Abstract: Motivation: Animal models are widely used in biomedical research for reasons ranging from practical to ethical. An important issue is whether rodent models are predictive of human biology. This has been addressed recently in the framework of a series o...
Inter-species inference of gene set enrichment in lung epithelial cells from proteomic and large transcriptomic datasets.
Publication Type: Academic Journal
Source(s): Bioinformatics (Oxford, England) [Bioinformatics] 2015 Feb 15; Vol. 31 (4), pp. 492-500. Date of Electronic Publication: 2014 Aug 24.
Abstract: Motivation: Translating findings in rodent models to human models has been a cornerstone of modern biology and drug development. However, in many cases, a naive 'extrapolation' between the two species has not succeeded. As a result, clinical trials of ...
Inter-species pathway perturbation prediction via data-driven detection of functional homology.
Publication Type: Academic Journal
Source(s): Bioinformatics (Oxford, England) [Bioinformatics] 2015 Feb 15; Vol. 31 (4), pp. 501-8. Date of Electronic Publication: 2014 Aug 22.
Abstract: Motivation: Experiments in animal models are often conducted to infer how humans will respond to stimuli by assuming that the same biological pathways will be affected in both organisms. The limitations of this assumption were tested in the IMPROVER Sp...
Measuring the effect of inter-study variability on estimating prediction error.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2014 Oct 17; Vol. 9 (10), pp. e110840. Date of Electronic Publication: 2014 Oct 17 (Print Publication: 2014).
Abstract: Background: The biomarker discovery field is replete with molecular signatures that have not translated into the clinic despite ostensibly promising performance in predicting disease phenotypes. One widely cited reason is lack of classification consist...